Copper-catalyzed decarboxylative trifluoromethylation of allylic bromodifluoroacetates.

نویسندگان

  • Brett R Ambler
  • Ryan A Altman
چکیده

The development of new synthetic fluorination reactions has important implications in medicinal, agricultural, and materials chemistries. Given the prevalence and accessibility of alcohols, methods to convert alcohols to trifluoromethanes are desirable. However, this transformation typically requires four-step processes, specialty chemicals, and/or stoichiometric metals to access the trifluoromethyl-containing product. A two-step copper-catalyzed decarboxylative protocol for converting allylic alcohols to trifluoromethanes is reported. Preliminary mechanistic studies distinguish this reaction from previously reported Cu-mediated reactions.

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عنوان ژورنال:
  • Organic letters

دوره 15 21  شماره 

صفحات  -

تاریخ انتشار 2013